Selecting a Solvent
If the solvent is not specified, you will need to test a variety of
solvents to determine what will work best for the solute you are trying
to recrystallize. This testing can be accomplished by putting a small
amount of your solute (about the size of a pea) into three small test
tubes. In each test tube, place 0.5 mL of each potential solvent. Use a
stirring rod to agitate the solute or "flick" the bottom of the test
tube with one finger while holding the top with the other hand. If the
solute dissolves at room temperature with stirring, the solvent should
be discarded as a potential recrystallization solvent. If the sample
does not dissolve at room temperature, place the test tube in a hot
water bath and stir the contents. If the solute partially dissolves add
more solvent and continue stirring. If the solute dissolves completely,
remove it from heat and place it in an ice-water bath. If crystals do
not form, try to scratch the inside of the test tube with a stirring
rod. If crystals form, you have found an appropriate recrystallization
solvent; if no crystals form, keep looking for the right match between
solvent and solute.
If no solvent can be found, perhaps you will need to use a mixed solvent. If two solvents in which the solute has different solubility characteristics are mixed, sometimes an appropriate solvent can be found. For instance, if your solute is insoluble in water but soluble in ethanol at room temperature, a mixture of the two solvents may produce an appropriate solvent in which the solute is insoluble at room temperature but very soluble at a significantly higher temperature. To find the proper proportion of water to ethanol in this example, first, completely dissolve your solute in ethanol at room temperature. Then, begin to add water until the solution becomes cloudy (this is because all of the solute is no longer held in solution). Add just enough ethanol to make your solution clear and begin your recrystallization procedure.
*The dielectric constant is a measure of the solvent's ability to
separate ions. In general, ionic compounds are more soluble in solvents
with high dielectric constants.
If no solvent can be found, perhaps you will need to use a mixed solvent. If two solvents in which the solute has different solubility characteristics are mixed, sometimes an appropriate solvent can be found. For instance, if your solute is insoluble in water but soluble in ethanol at room temperature, a mixture of the two solvents may produce an appropriate solvent in which the solute is insoluble at room temperature but very soluble at a significantly higher temperature. To find the proper proportion of water to ethanol in this example, first, completely dissolve your solute in ethanol at room temperature. Then, begin to add water until the solution becomes cloudy (this is because all of the solute is no longer held in solution). Add just enough ethanol to make your solution clear and begin your recrystallization procedure.
| Solvent | B.P. | Dielectric Constant* | Safety Concerns |
|---|---|---|---|
| Water | 100 | 78.4 | None |
| Ethanol | 78 | 24.5 | Flammable; irritating to the eyes, respiratory system, and skin |
| Acetone | 56 | 20.6 | Flammable; Irritating to the eyes; Vapors may cause drowsiness or dizziness |
| Tetrahydrofuran | 66 | 7.58 | Flammable; Harmful if swallowed; Irritating to the eyes, skin, and respiratory system |
| Ethyl acetate | 78 | 6.02 | Flammable; Irritating to the eyes; Vapors may cause drowsiness or dizziness |
| Cyclohexane | 81 | 1.89 | Flammable; May damage lungs if swallowed; Vapors may cause drowsiness or dizziness |
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